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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '250ff1c7bfe302440f52365c2f94fd0dcb76fe171bd02453c3ec6e0d2b581fde' 
  AND token = 'WuTtPXkf/+dLuH9NyDOoDzX+POj21ITnuefbkgAh3is=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}