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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b9f621f6f2e8f2bbcb6cc339870176b00de0281a91dbc575b8d70be386d82d01' 
  AND token = 'yFkw+Oal5kwOYzj36zEuD6mmz0eQDSy4e67eg//ch3g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}