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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5381246798493ae5b02670c4dea1906e2f08e65dd193dc509ef046d7febb4792' 
  AND token = 'EXWa6PE9h3VHKOD9oXRGsc1WuKBUOgUp4TFb9An/CMU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}