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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3a56cc1cdcb3da2005ffd6331ba8016a8aa4cffde6e21378b0497940626532b1' 
  AND token = 'GxNC8VEAk7cLTXXFoaX/YCzd1YSEVaXO62iSuE7Xo4U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}