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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '533105205b32d7296fa8fbfe40a6816eb2fd4d1ee90ed03fbaf84c446d9ab3ee' 
  AND token = 'kR2lhaQ3MhXrA+xICLloEhRGFX08NUXqWS2XGEc34OM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}