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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b80b8709ef3847efcd98664eb5a1a6ded9ed29e9d19513b96756b473c1a7d86' 
  AND token = 'yiI8o+JJdeH00VFk914NYv6SY3LKWB+G4jfIGxrn2Yw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}