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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222f53ace5a00e9f22a7e2e52006b131d576a56e8199737c8b8339e273c4405e' 
  AND token = '+egZnjK9oQI+Q1iyy4DEWnqhbC6u4wuHhcKJz7Ouw8A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}