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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cc78165bb50a6a805a748153db57c792a1c3b48e2fd0163aeb42aa74d446d8d3' 
  AND token = 'hY6e7DowGDCq+JInI8de08DhtUAMVVsBNrZcTDMMYmQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}