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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '190f52f03858134dbb2dac55453e47a17de7f042d2b5f4e55a2e634747b39d7a' 
  AND token = 'VkYXq+BC5xIupmxIsT1aqD/TkEALPf9wDorjHITNXzk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}