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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5642c88e707d1c2e8c42bb278cc0cdc358170c40ba1cebe1bd3541214e9a49be' 
  AND token = 'hOxGBHNHXzSvC+F9yjo9PoS5QjCSMV9MLm+FGZu18yQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}