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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '85c225e042a0c1a5680ff7b82c9a4b2cf077458d5f9e55b5c7d818ed65431178' 
  AND token = 'd78dKrxAO/pxTy+3erOvTSB4Bg1y9B2Qyrib+7AMbds=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}