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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '435b5c2cef3f4386b84ea7e8f94c55ff81a2f3bed1e7b57548e71b92bb471642' 
  AND token = 'eMHCyd7lvHaK41qt1bItlUBis5LzOanj6DnTbrTr6+w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}