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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ea2e1cbffbd0d29c526addda499217297eb8f75db3d755a75ff918d2f18e45b1' 
  AND token = 'KDqmHuDxLCt6BsiVuYX44TA9k8rGJNVvzK1019AHq4w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}