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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ec25ca808cdf4c67e0843e50fef2bc0eddbc82bc73f23f08d0efbac353c47722' 
  AND token = '2zPRmDAR4A/KpUsZzeaVtPyPvBdlieAYLFY57N/r9V8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}