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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd85e82dba3522045fa8444a98d4f0351bcc45ded0f2958d59bcb5e9c80c44f48' 
  AND token = 'A6GY1VtjTdrmVy00e5KuKhpS8vNDwdJ+z+BoJ9NxKso=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}