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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e16cef33a94e48688b0ff0b0a700977a0f63125cdda87e3da576cd0b8645ad12' 
  AND token = '+8zQaJ0vC//1K9pr2AeNUctVmdeDczEbsAAjtoY0S5g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}