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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '781c74efa248310c61cd836187816710e2119a381ce923030138e2dd1524db33' 
  AND token = 'Z2gVP6nR/qwpGLAIvXyAIsBkeqY50rp1P5mztsYxqzk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}