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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a5a6ef00fa177fa2aeb220abf18112ada376e711a2ac9a0cc07df50dadd27331' 
  AND token = 'oPHGNzu+vi0yzPbe8lzbrBqiHRPXjEZvldSDVUOd1zk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}