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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54d81bdcd025f92e039565d660361bf3bb3399bf3f7ffcb6dc878eadd5a949f4' 
  AND token = 'XSiyIoxEB9yfsD00kVe5t7VYpoXsVKP1QnXiuUrcrwQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}