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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e99f57be41a2b359eaf26588e080e103047d768a1718eb994e0639633469b341' 
  AND token = 'R1cQVn5B+dCPQjN/foq6R4UReJOQwJjdJJ5jT8bRZx8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}