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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '782ff9dfe9c0f068c2deae86b1a6db15a35e2242d2956c9e361cbf0e43d1bf47' 
  AND token = 'F3Vt3QIjmkElxOS2Oi5+gn4GZ4BcC9bswKINjj9hMg0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}