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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '122201ba496504711522ee9fee301f07cd22a65e6d2021c141aeb0887e41cc2c' 
  AND token = 'QJ5PtOghgAJ0ZBJnBL1DbUNb8RbLjljLAFnSUobFBmM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00044

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}