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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53d8727a3c03a71b599d57803dc261be55c5abfb1e8cdfc073c8ac699c48eb22' 
  AND token = 'gaJ0jSBQT9aTMjFoebA8RUwSuAF6SfDoi5gxxBTY9bo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}