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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c192b6648d085ab6230f12f5dd63aaf0cedc509054fffbc3f5b1ac556bf6be3c' 
  AND token = 'cqNw6fqFrjhbouB+BaoirMtb5yHPp5oX2xjC82XWeBQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}