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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66142a3e40426ed3c95d5e594c1770d9e8bae945bc027eb78faeb3155f5c7494' 
  AND token = 'tJg3tQdENbrSBRDtuYpnZNEi2gR2fyxfD1rUVs6IO0Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}