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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '741d3490c2d11724ba8abd657eddfd5321f8cf0a9c2d2c5314cd2a71b8c4e225' 
  AND token = 'X5z4JLLTAa0VIxTBGhsDlYQP5C1jNIVQiANthCg4C4Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00054

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}