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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '121840ddd8aac978fa641c981ac8dea369ca9b06031903ec2e02356d29b52aaa' 
  AND token = 'Pv1KJ8KdcxzxEKMJ2AL+YrJBbEde4SrMxJLXQY7h6wI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}