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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b21a5f770f33c1dc9c829eba71eed04abef0c09799a86061808267d630051302' 
  AND token = 'dR48AuAN+4r53u0y2mTLthmq+uctzfxLKOu3N2i8Ygk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}