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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c5261fb7fa0207f4a76a243da0cbec3d34d3ac427746fc25be477be94e28edf4' 
  AND token = 'R330N+Vgzq6tG5BPMNMK1oCfjmMGGa0Z+0KA6JpuTYU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}