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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '38c289bc62a35e97c3a54c0a59e87b8465d95e2873681680e1a32d914e0e2209' 
  AND token = 'sjTEI+SLzyy79G3YeWgh3bwqNnBQfdY6ezQ05RKoRSw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}