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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16c53cb48679c26e238574b6b3b03ebf64f174729f22f109b021c20959d1c02c' 
  AND token = 'HvQAOs7qu1XpT2I7QWBlBbfrGwKL1zX8f7B6S4uNg3U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}