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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0a1fc378b2aa78903648d3bed5cb3e6252eb9a7d3ca919687df36fd494d04073' 
  AND token = 'nM+hX0ahcK46i6STwJeBseGlVYFYeMA+p5KdTja1zSw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}