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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6486f1b588d72ad2c53e82456de33c26b806dcdf600da55ac99c60099056d78a' 
  AND token = 'j+w1LotYk3aOSAagfTNYPD3qKFiaFN0Q3LAvb3Orppo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}