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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25a12e103f83502eae206d0740404a34a5807d5e6bdff5f39ff2755083eda28a' 
  AND token = 'ohq/CO1UK5Imsmk4GUT1pHHqhpoQ5YnckTRPohxD2Jg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}