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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de9c45172968f58b9a2ab0da242cf67a0573a7f957fdbeb053c8fc25c5a1e6c7' 
  AND token = 'Ir7xekdLALOOsQ0Bn+K+k1f6PBmhkbDlA0mWlw1kH10=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00043

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}