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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e46b09634c95ebb0cac922a6f52ae6728d89d3062dca6aabbb9f986b640631c' 
  AND token = '+Tr//Rj1DpXB0I9/zn+i1JyAuRtW1xKLjzpqOdWtSz4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}