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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78ed64bab0a69ebb6c0eb6c19ae7f07373a780c32ac62f68c7c9edb13b612a50' 
  AND token = 'l50RSXLwmF72aY3SzBhkJeeWHhWiT1uWkqHvMtO9vdo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00065

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}