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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81b4270d2091ca7e25452a47256d275778280062b7b0bd3ba227203781d97daf' 
  AND token = 'UM72mHopBPuecRRDxVE/CnHAHuosdtSATMPXl8ggYEg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}