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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0cd9e10dd20d98cb9424415d2a109cf72bd9b249ea5c5a715b988a1b987f3301' 
  AND token = 'JcuriuwJwgW7gq1VTPLVxWsh8NJrgu5V3uyNc4q2at8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}