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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43781bb81e1c677888aac4d4b8e45ca1de01b38b638e6cce2dca84edc88321a8' 
  AND token = '1yCkBN/nGKnpZ4MK45KkC8IULh8fDKmd28bgIpDJ6Kg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}