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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48e3104057a48c86b67b2b1a1386cb92bf63359cf892b4e3a6e8c052d506931a' 
  AND token = 'XE2jUaBBQX0Z+iliZWAJNiNcsa414dQgmcjnBq4fF9I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}