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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49e3759e5548a24bc49f271051aa9bd66fb8b13a385f29212654c6f8a0ec7334' 
  AND token = '/9YMQT+UoY92twa0267fxlISQMW3+9GcxsO9TYLBzUw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00069

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}