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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b22260458c7ac12f0d65bf6d275e4e1edbb678cb6a86456de5bce397bb1d001b' 
  AND token = 'iYisnDmRA/XfPysZjn//aF504QiHsxMi/Uh5ob/m3bY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00050

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}