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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49b4497fe338bbe443b9b3fe7d8366640e6e7a2c4c11da307d40b5b9e375bce7' 
  AND token = 'Ag81tO6KvWM1rAfFwv6s1EK97dqtbw5qN2Zfq3CeF6I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}