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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49a47f4469b3d05e61f21cce3532c7a803ff1c75903f8ef7e62bb3f53265ee18' 
  AND token = 'VD1GkF2BkGaR0JiKABL+P+rfJyib8K/SY1aRaVYSFk4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}