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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6b49521a3e5e777e245228c265510487962465e6148b44c4315ea07386a4d811' 
  AND token = 'BYaBIeXcm5N721pzage2dKCJX+GEoM978BQaclBfguo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}