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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b6460ef2de5bf196faef2ef7335ff02d18dcf1f73cbfe9b72e9d35368da677c' 
  AND token = 'rDaaS3DDRYjWoDj21uhNHGxsIpNb3SyxkvfjIZUGBu4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}