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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e42f0af837951f5d8cf443d71549d7dbfff16419b25d996e263899450e35b953' 
  AND token = 'ZrXHjXrfBNa0n2CY402FFdv2JLa4YhUxpj5RytyXZo8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}