SELECT 
  pfv.feature_id, 
  pfv.product_id, 
  pfv.variant_id, 
  gp.group_id 
FROM 
  cscart_product_features_values AS pfv 
  INNER JOIN cscart_product_variation_group_products AS gp ON pfv.product_id = gp.product_id 
  INNER JOIN cscart_product_variation_group_features AS gpf ON gpf.group_id = gp.group_id 
  AND gpf.feature_id = pfv.feature_id 
WHERE 
  pfv.lang_code = 'en' 
  AND gp.group_id IN (21, 19, 17, 15, 14, 12)

Query time 0.00242

JSON explain

{
  "query_block": {
    "select_id": 1,
    "cost_info": {
      "query_cost": "191.02"
    },
    "nested_loop": [
      {
        "table": {
          "table_name": "gpf",
          "access_type": "index",
          "possible_keys": [
            "PRIMARY",
            "idx_group_id"
          ],
          "key": "PRIMARY",
          "used_key_parts": [
            "feature_id",
            "group_id"
          ],
          "key_length": "6",
          "rows_examined_per_scan": 21,
          "rows_produced_per_join": 11,
          "filtered": "52.38",
          "using_index": true,
          "cost_info": {
            "read_cost": "4.19",
            "eval_cost": "2.20",
            "prefix_cost": "6.39",
            "data_read_per_join": "1K"
          },
          "used_columns": [
            "feature_id",
            "group_id"
          ],
          "attached_condition": "(`atulecarter_atul_demo2`.`gpf`.`group_id` in (21,19,17,15,14,12))"
        }
      },
      {
        "table": {
          "table_name": "pfv",
          "access_type": "ref",
          "possible_keys": [
            "PRIMARY",
            "fl",
            "lang_code",
            "product_id",
            "fpl",
            "idx_product_feature_variant_id"
          ],
          "key": "PRIMARY",
          "used_key_parts": [
            "feature_id"
          ],
          "key_length": "3",
          "ref": [
            "atulecarter_atul_demo2.gpf.feature_id"
          ],
          "rows_examined_per_scan": 11,
          "rows_produced_per_join": 120,
          "filtered": "99.82",
          "using_index": true,
          "cost_info": {
            "read_cost": "15.49",
            "eval_cost": "24.16",
            "prefix_cost": "46.08",
            "data_read_per_join": "93K"
          },
          "used_columns": [
            "feature_id",
            "product_id",
            "variant_id",
            "lang_code"
          ],
          "attached_condition": "(`atulecarter_atul_demo2`.`pfv`.`lang_code` = 'en')"
        }
      },
      {
        "table": {
          "table_name": "gp",
          "access_type": "eq_ref",
          "possible_keys": [
            "PRIMARY",
            "idx_group_id"
          ],
          "key": "PRIMARY",
          "used_key_parts": [
            "product_id",
            "group_id"
          ],
          "key_length": "6",
          "ref": [
            "atulecarter_atul_demo2.pfv.product_id",
            "atulecarter_atul_demo2.gpf.group_id"
          ],
          "rows_examined_per_scan": 1,
          "rows_produced_per_join": 120,
          "filtered": "100.00",
          "using_index": true,
          "cost_info": {
            "read_cost": "120.78",
            "eval_cost": "24.16",
            "prefix_cost": "191.02",
            "data_read_per_join": "1K"
          },
          "used_columns": [
            "product_id",
            "group_id"
          ]
        }
      }
    ]
  }
}