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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b541bf43c0d2e627c1032a570a7e73498aa60ed7af03be05b7aec5c01904bf82' 
  AND token = 'RuKOCXPU4eLfXcrp9xWBvFiZsOiifnXMQui9ScsAzzA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}